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CheChung Yeh, Ph.D.

Specialist

Contact Information

2340 Sutter Street. S-231
San Francisco, CA 94115
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  • National Taiwan University B.S. Zoology, 1987
  • University of Kentucky Ph.D. Toxicology, 1998
  • University California, San Francisco Postdoc, 1998-2001.

My research goal is about the integration of advancement in the fields of molecular and cellular sciences into the application for the future treatment of thoracic and cardiovascular disease. As a co-director with laboratory principal investigator, Dr. Michael Mann, we development a translation research program focusing on the biology of heart failure, with a particular emphasis on molecular pathways that may provide novel means of intervening in the progression of this disease process.

Dr. Yeh has been instrumental in the effort to develop a number of unique models for studying the role of molecular and genetic interventions both in surgical reconstructive approaches and in cardiac cell transplantation strategies. Additionally, the laboratory is involved in successful development and validation of the first practical molecular prognostic assay for early stage non-small cell lung cancer. By employing the technique from above study, we are currently analyzing the cellular signaling markers of tumor specimens that have been collected from sarcoma patients undergoing surgical treatment at UCSF.

Yeh, C.C., Malhotra, D., Li, H., Nicholas, S., Tu R., Mann MJ. Surgical ventricular reconstruction in mice: Elucidating potential targets for combined molecular/surgical intervention. J Thor Cardiovasc Surg. 137(4):942-9, 2009.

Yeh, C.C., Li, H., Malhotra, D., Huang, M.C., Zhu, B.Q., Goetzl, E.J., Vessey, D.A., Karliner, J.S., Mann, MJ. Sphingolipid signaling and treatment during remodeling of the uninfarcted ventricular wall after myocardial infarction. Am J Physiol Heart Circ Physiol. 296(4):H1193-9, 2009.

Mahimkar R., Nguyen A., Mann MJ, Yeh C.C., Zhu B.Q., Karliner J.S., Lovett D.H. Cardiac transgenic matrix metalloproteinase-2 expression induces myxomatous valve degeneration: a potential model of mitral valve prolapse disease. Cardiovasc Pathol. 18(5):253-61, 2009.

Li, H., Malhotra, D., Yeh, C.C., Tu, R., Zhu, B.Q., Birger, N., Wisneski, A., Cha, J., Karliner, J.S., Mann, MJ. Myocardial survival signaling in response to stem cell transplantation. J Am Coll Surg. 208(4):607-13.

Wang, G, Yeh C.C., Jensen B, Mann MJ, Simpson PC, Baker AJ. Heart failure switches the RV {alpha}1-adrenergic inotropic response from negative to positive. Am J Physiol Heart Circ Physiol 298(3):H913-20, 2010.

Yeh C.C., Li H., Malhotra D., Turcato S., Nicholas S., Tu R., Zhu B.Q., Cha J., Swigart P.M., Myagmar B.E., Baker A.J., Simpson P.C., Mann M.J.. Distinctive ERK and p38 signaling in remote and infarcted myocardium during post-MI remodeling in the mouse. J Cell Biochem. 109(6):1185-91, 2010.

Wall S.T., Yeh C.C., Tu R.Y.K., Mann M.J., Healy K.E.. Biomimetic Matrices for Myocardial Stabilization and Stem Cell Transplantation. J Biomed Mater Res A. 95(4):1055-66, 2010.

Kratz JR, He J, Van Den Eeden SK, Zhu ZH, Gao W, Pham PT, Mulvihill MS, Ziaei F, Zhang H, Su B, Zhi X, Quesenberry CP, Habel LA, Deng Q, Wang Z, Zhou J, Li H, Huang MC, Yeh CC, Segal MR, Ray MR, Jones KD, Raz DJ, Xu Z, Jahan TM, Berryman D, He B, Mann MJ, Jablons DM. A practical molecular assay to predict survival in resected non-squamous, non-small-cell lung cancer: development and international validation studies. Lancet. 379(9818):823-32, 2012.

Yeh CC, Malhotra D, Yang YL, Xu Y, Fan Y, Li H, Mann MJ. MEK1-induced physiological hypertrophy inhibits chronic post-myocardial infarction remodeling in mice. J Cell Biochem. 114(1):47-55, 2013.

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