Discovering Cellular and Molecular Strategies to Treat the Ravages of Cancer Heart Failure

The Cardiothoracic Translational Research Laboratory is focused on turning a deeper understanding of the complex biology of cancer and heart failure into a new generation of cellular and molecular therapies. The lab’s cancer research focuses on untangling the mystery of metastasis, a pathologic phenomenon that remains both poorly understood and still responsible for most cancer deaths. Heart failure, in turn, affects more than 5 million Americans and is already the greatest single economic burden in American health care, yet no existing therapies can either halt or reverse the disease process.

The Translational Research Lab is exploring the molecular signatures of metastatic tumors, which in turn may reveal both earlier and more precise diagnostic capabilities as well as novel treatment mechanisms to prevent or arrest metastasis. It’s decade-long exploration of the molecular controls of cardiac cell growth and adaptation is beginning to yield novel pathways for intervention that may, for the first time, allow the reversal of cardiac structural and functional deterioration.

Recent Publications

Yeh CC, Li H, Malhotra D, Turcato S, Nicholas S, Tu R, Zhu BQ, Cha J, Swigart PM, Myagmar BE, Baker AJ, Simpson PC, Mann MJ
Distinctive ERK and p38 signaling in remote and infarcted myocardium during post-MI remodeling in the mouse.
Journal of cellular biochemistry, Apr-15-2010; 1096: 1185-91.
Mahimkar R, Nguyen A, Mann M, Yeh CC, Zhu BQ, Karliner JS, Lovett DH
Cardiac transgenic matrix metalloproteinase-2 expression induces myxomatous valve degeneration: a potential model of mitral valve prolapse disease.
Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology, 185: 253-61.  Epub 2008 Oct 1.
Yeh CC, Li H, Malhotra D, Huang MC, Zhu BQ, Goetzl EJ, Vessey DA, Karliner JS, Mann MJ
Sphingolipid signaling and treatment during remodeling of the uninfarcted ventricular wall after myocardial infarction.
American journal of physiology. Heart and circulatory physiology, Apr-01-2009; 2964: H1193-9.  Epub 2009 Feb 20.
Yeh CC, Malhotra D, Li H, Nicholas S, Tu R, Mann MJ
Surgical ventricular reconstruction in mice: elucidating potential targets for combined molecular/surgical intervention.
The Journal of thoracic and cardiovascular surgery, Apr-01-2009; 1374: 942-9.  Epub 2009 Jan 12.
Li H, Malhotra D, Yeh CC, Tu R, Zhu BQ, Birger N, Wisneski A, Cha J, Karliner JS, Mann MJ
Myocardial survival signaling in response to stem cell transplantation.
Journal of the American College of Surgeons, Apr-01-2009; 2084: 607-13.
Mann MJ, Tseng E, Ratcliffe M, Strattman G, De Silva A, Demarco T, Achorn N, Moskalik W, Hoopes C
Use of bivalirudin, a direct thrombin inhibitor, and its reversal with modified ultrafiltration during heart transplantation in a patient with heparin-induced thrombocytopenia.
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, Feb-01-2005; 242: 222-5.
Vlasenko VV, Matskivskiĭ VI, Pen'kov FM, Fedorov VD
[An analysis of fluctuations in distributed biological systems: potentials and use of an automated correlation Doppler spectrometer in studying the movement of microorganisms].
Nauchnye doklady vyssheĭ shkoly. Biologicheskie nauki, 10: 105-10.
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